Unexpected Widespread Bone Metastases from a BRAF K601N Mutated Follicular Thyroid Carcinoma within a Previously Resected Multinodular Goiter.

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作者： Andrea,Repaci ^[1] ; Nicola,Salituro ^[2] ; Valentina,Vicennati ^[2] ; Fabio,Monari ^[3] ; Ottavio,Cavicchi ^[4] ; Dario,de Biase ^[5] ; Alessia,Ciarrocchi ^[6] ; Giorgia,Acquaviva ^[7] ; Antonio,De Leo ^[7] ; Elisa,Gruppioni ^[8] ; Uberto,Pagotto ^[2] ; Giovanni,Tallini ^[7]

作者单位： Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. andrea.repaci@aosp.bo.it. ^[1] Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy. ^[2] Radiotherapy Unit, Policlinico Di Sant'Orsola, University of Bologna, Bologna, Italy. ^[3] Department of Otolaryngology, Policlinico Di Sant'Orsola, University of Bologna, Bologna, Italy. ^[4] Department of Pharmacy and Biotechnology (FaBit), Molecular Diagnostic Unit, University of Bologna, Azienda USL Di Bologna, Bologna, Italy. ^[5] Laboratory of Translational Research, Azienda Unità Sanitaria Locale-IRCCS Di Reggio Emilia, Reggio Emilia, Italy. ^[6] Department of Experimental, Diagnostic and Specialty Medicine, Anatomic Pathology - Molecular Diagnostic Unit, University of Bologna, Azienda USL Di Bologna, Bologna, Italy. ^[7] Department of Pathology, Azienda Ospedaliero-Universitaria Di Bologna IRCCS Policlinico S.Orsola-Malpighi, Bologna, Italy. ^[8]

关键词 BRAF mutation Bone metastases Chromosome 19 Follicular thyroid carcinoma K601N Next-generation sequencing

主题词人类(Humans);腺癌, 滤泡性(Adenocarcinoma, Follicular);甲状腺肿(Goiter);突变(Mutation);原癌基因蛋白质B-raf(Proto-Oncogene Proteins B-raf);甲状腺肿瘤(Thyroid Neoplasms);骨肿瘤(Bone Neoplasms)

DOI 10.1007/s12022-021-09698-7

PMID 34843063

发布时间 2022-12-05

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