Severe COVID-19 infection is associated with aberrant cytokine production by infected lung epithelial cells rather than by systemic immune dysfunction.

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第一作者： Sherin J,Rouhani

第一单位： Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL.

作者： Sherin J,Rouhani ^[1] ; Jonathan A,Trujillo ^[1] ; Athalia R,Pyzer ^[1] ; Jovian,Yu ^[1] ; Jessica,Fessler ^[2] ; Alexandra,Cabanov ^[2] ; Emily F,Higgs ^[2] ; Kyle R,Cron ^[2] ; Yuanyuan,Zha ^[3] ; Yihao,Lu ^[4] ; Jeffrey C,Bloodworth ^[1] ; Mustafa Fatih,Abasiyanik ^[5] ; Susan,Okrah ^[5] ; Blake A,Flood ^[2] ; Ken,Hatogai ^[1] ; Michael Yk,Leung ^[2] ; Apameh,Pezeshk ^[2] ; Lara,Kozloff ^[1] ; Robin,Reschke ^[1] ; Garth W,Strohbehn ^[2] ; Carolina Soto,Chervin ^[1] ; Madan,Kumar ^[1] ; Stephen,Schrantz ^[6] ; Maria Lucia,Madariaga ^[7] ; Kathleen G,Beavis ^[8] ; Kiang-Teck J,Yeo ^[2] ; Randy F,Sweis ^[2] ; Jeremy,Segal ^[1] ; Savaş,Tay ^[2] ; Evgeny,Izumchenko ^[5] ; Jeffrey,Mueller ^[1] ; Lin S,Chen ^[2] ; Thomas F,Gajewski ^[4]

作者单位： Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL. ^[1] Department of Pathology, University of Chicago, 5841 S. Maryland Ave, MC2115, Chicago, IL. ^[2] The Human Immunological Monitoring Facility, University of Chicago, Chicago, IL 60637. ^[3] Department of Public Health Sciences, The University of Chicago, Chicago, IL 60637. ^[4] Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL, USA. ^[5] Department of Pediatrics, Section of Infectious Diseases, University of Chicago. ^[6] Department of Medicine, Section of Infectious Diseases, University of Chicago. ^[7] Department of Surgery, University of Chicago. ^[8]

关键词 COVID-19 respiratory failure severe COVID-19 pathophysiology

DOI 10.21203/rs.3.rs-1083825/v1

PMID 34845442

发布时间 2023-10-20

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Severe COVID-19 infection is associated with aberrant cytokine production by infected lung epithelial cells rather than by systemic immune dysfunction.

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Severe COVID-19 infection is associated with aberrant cytokine production by infected lung epithelial cells rather than by systemic immune dysfunction.

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