HRD1-mediated METTL14 degradation regulates m<sup>6</sup>A mRNA modification to suppress ER proteotoxic liver disease.-论文-万方医学网

第一作者： Juncheng,Wei

第一单位： Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: juncheng.wei@northwestern.edu.

作者： Juncheng,Wei ^[1] ; Bryan T,Harada ^[2] ; Dan,Lu ^[3] ; Ruihua,Ma ^[4] ; Beixue,Gao ^[5] ; Yanan,Xu ^[5] ; Elena,Montauti ^[5] ; Nikita,Mani ^[5] ; Shuvam M,Chaudhuri ^[5] ; Shana,Gregory ^[5] ; Samuel E,Weinberg ^[5] ; Donna D,Zhang ^[6] ; Richard,Green ^[7] ; Chuan,He ^[2] ; Deyu,Fang ^[8]

作者单位： Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: juncheng.wei@northwestern.edu. ^[1] Department of Chemistry and Department of Biochemistry and Molecular Biology, The University of Chicago, Chicago, IL 60637, USA; Howard Hughes Medical Institute, The University of Chicago, Chicago, IL 60637, USA. ^[2] Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA. ^[3] Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. ^[4] Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. ^[5] Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA. ^[6] Division of Gastroenterology and Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. ^[7] Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. Electronic address: fangd@northwestern.edu. ^[8]

主题词腺嘌呤(Adenine);动物(Animals);细胞凋亡(Apoptosis);疾病模型, 动物(Disease Models, Animal);内质网(Endoplasmic Reticulum);HEK293细胞(HEK293 Cells);Hep G2细胞(Hep G2 Cells);人类(Humans);肝(Liver);肝疾病(Liver Diseases);甲基转移酶类(Methyltransferases);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 近交NOD(Mice, Inbred NOD);小鼠, 基因敲除(Mice, Knockout);小鼠, SCID(Mice, SCID);NIH 3T3细胞(NIH 3T3 Cells);转录因子CHOP(Transcription Factor CHOP);泛素蛋白连接酶类(Ubiquitin-Protein Ligases);泛素化(Ubiquitination);α1抗胰蛋白酶(alpha 1-Antitrypsin);α1抗胰蛋白酶缺乏症(alpha 1-Antitrypsin Deficiency)

DOI 10.1016/j.molcel.2021.10.028

PMID 34847358

发布时间 2025-01-18

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HRD1-mediated METTL14 degradation regulates m<sup>6</sup>A mRNA modification to suppress ER proteotoxic liver disease.

Molecular cell

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Molecular cell

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HRD1-mediated METTL14 degradation regulates m<sup>6</sup>A mRNA modification to suppress ER proteotoxic liver disease.

Molecular cell

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Molecular cell

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