首页> Clinical epigenetics> Ionizing radiations induce shared epigenomic signatures unraveling adaptive mechanisms of cancerous cell lines with or without methionine dependency.

Ionizing radiations induce shared epigenomic signatures unraveling adaptive mechanisms of cancerous cell lines with or without methionine dependency.

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第一作者： Youssef,Siblini

第一单位： INSERM, UMR_S1256, NGERE (Nutrition, Genetics, and Environmental Risk Exposure), Faculty of Medicine of Nancy, University of Lorraine, 9 Avenue de la Forêt de Haye, 54000, Vandoeuvre-lès-Nancy, Nancy, France.

作者： Youssef,Siblini ^[1] ; Céline,Chéry ^[2] ; Pierre,Rouyer ^[1] ; Jérémie,Raso ^[1] ; Amélia,Julien ^[1] ; Sébastien,Hergalant ^[1] ; Aurélie,François ^[3] ; Lina,Bezdetnaya ^[4] ; Guillaume,Vogin ^[5] ; Jean-Louis,Guéant ^[6] ; Abderrahim,Oussalah ^[7]

作者单位： INSERM, UMR_S1256, NGERE (Nutrition, Genetics, and Environmental Risk Exposure), Faculty of Medicine of Nancy, University of Lorraine, 9 Avenue de la Forêt de Haye, 54000, Vandoeuvre-lès-Nancy, Nancy, France. ^[1] INSERM, UMR_S1256, NGERE (Nutrition, Genetics, and Environmental Risk Exposure), Faculty of Medicine of Nancy, University of Lorraine, 9 Avenue de la Forêt de Haye, 54000, Vandoeuvre-lès-Nancy, Nancy, France.;Department of Molecular Medicine and Personalized Therapeutics, Department of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, 54000, Vandoeuvre-lès-Nancy, France.;Reference Center for Inborn Errors of Metabolism (ORPHA67872), University Hospital of Nancy, 54000, Vandoeuvre-lès-Nancy, France. ^[2] Lorraine Institute of Oncology, 54000, Nancy, France. ^[3] Lorraine Institute of Oncology, 54000, Nancy, France.;CNRS, UMR_7039, CRAN (Centre de Recherche en Automatique de Nancy), Faculty of Medicine of Nancy, University of Lorraine, 54000, Vandoeuvre-lès-Nancy, France. ^[4] UMR_7365, IMoPA (Ingénierie Moléculaire Et Ingénierie Articulaire), Faculty of Medicine of Nancy, CNRS-UL, University of Lorraine, 54000, Vandoeuvre-lès-Nancy, France. ^[5] INSERM, UMR_S1256, NGERE (Nutrition, Genetics, and Environmental Risk Exposure), Faculty of Medicine of Nancy, University of Lorraine, 9 Avenue de la Forêt de Haye, 54000, Vandoeuvre-lès-Nancy, Nancy, France. jean-louis.gueant@univ-lorraine.fr.;Department of Molecular Medicine and Personalized Therapeutics, Department of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, 54000, Vandoeuvre-lès-Nancy, France. jean-louis.gueant@univ-lorraine.fr.;Reference Center for Inborn Errors of Metabolism (ORPHA67872), University Hospital of Nancy, 54000, Vandoeuvre-lès-Nancy, France. jean-louis.gueant@univ-lorraine.fr. ^[6] INSERM, UMR_S1256, NGERE (Nutrition, Genetics, and Environmental Risk Exposure), Faculty of Medicine of Nancy, University of Lorraine, 9 Avenue de la Forêt de Haye, 54000, Vandoeuvre-lès-Nancy, Nancy, France. abderrahim.oussalah@univ-lorraine.fr.;Department of Molecular Medicine and Personalized Therapeutics, Department of Biochemistry, Molecular Biology, Nutrition, and Metabolism, University Hospital of Nancy, 54000, Vandoeuvre-lès-Nancy, France. abderrahim.oussalah@univ-lorraine.fr.;Reference Center for Inborn Errors of Metabolism (ORPHA67872), University Hospital of Nancy, 54000, Vandoeuvre-lès-Nancy, France. abderrahim.oussalah@univ-lorraine.fr. ^[7]

关键词 Aberrant methylation Epigenome alterations Epigenome-wide association study Glioblastoma Hepatocellular carcinoma Ionizing radiation Melanoma Metabolic adaptation in cancer Methionine dependency Radiation therapy Radioresistance

医学主题词适应, 心理学(Adaptation, Psychological);细胞系, 肿瘤(Cell Line, Tumor);DNA甲基化(DNA Methylation);表观基因组学(Epigenomics);人类(Humans);甲硫氨酸(Methionine);辐射, 电离(Radiation, Ionizing)

DOI 10.1186/s13148-021-01199-y

PMID 34852845

发布时间 2024-04-04

基金项目

3FI14040UHSK/la ligue contre le cancer (grand est/bourgogne franche comté, france) AAP-BMS_003_211/university of lorraine (pôle biologie médecine santé)

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