Systemic inflammasome activation and pyroptosis associate with the progression of amnestic mild cognitive impairment and Alzheimer's disease.

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第一作者： Wenjuan,Rui

第一单位： Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing, 210029, Jiangsu, China.

作者： Wenjuan,Rui ^[1] ; Hong,Xiao ^[2] ; Yi,Fan ^[2] ; Zhongxuan,Ma ^[1] ; Ming,Xiao ^[3] ; Sheng,Li ^[4] ; Jingping,Shi ^[5]

作者单位： Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing, 210029, Jiangsu, China. ^[1] Department of the Neuro-Psychiatric Institute, Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing, 210029, Jiangsu, China. ^[2] Department of Pharmacy, Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing, 210029, Jiangsu, China. ^[3] Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166, Jiangsu, China. ^[4] Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing, 210029, Jiangsu, China. lsls114@njmu.edu.cn. ^[5] Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing, 210029, Jiangsu, China. shijingping@njmu.edu.cn. ^[6]

关键词 Alzheimer’s disease Gasdermin D Inflammasome Interleukin-1β Neuroinflammation Pyroptosis