Identification and characterization of an atypical Gαs-biased β<sub>2</sub>AR agonist that fails to evoke airway smooth muscle cell tachyphylaxis.

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作者： Donghwa,Kim ^[1] ; Alina,Tokmakova ^[2] ; Lauren K,Lujan ^[1] ; Hannah R,Strzelinski ^[1] ; Nicholas,Kim ^[3] ; Maliheh,Najari Beidokhti ^[1] ; Marc A,Giulianotti ^[4] ; Amirhossein,Mafi ^[2] ; Jung-A A,Woo ^[5] ; Steven S,An ^[6] ; William A,Goddard ^[7] ; Stephen B,Liggett ^[8]

作者单位： Department of Medicine, University of South Florida Morsani College of Medicine, Tampa, FL 33612. ^[1] Materials and Process Simulation Center, California Institute of Technology, Pasadena, CA 91125. ^[2] Rutgers Institute for Translational Medicine and Science, New Brunswick, NJ 08901. ^[3] Center for Translational Science, Florida International University, Port St. Lucie, FL 34987. ^[4] Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33612. ^[5] Rutgers Institute for Translational Medicine and Science, New Brunswick, NJ 08901.;Department of Pharmacology, Rutgers-Robert Wood Johnson Medical School, The State University of New Jersey, Piscataway, NJ 08854. ^[6] Materials and Process Simulation Center, California Institute of Technology, Pasadena, CA 91125; wag@caltech.edu sliggett@usf.edu. ^[7] Department of Medicine, University of South Florida Morsani College of Medicine, Tampa, FL 33612; wag@caltech.edu sliggett@usf.edu.;Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL 33612. ^[8]

关键词 Gs asthma biasing β-agonist β-arrestin