换一批Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV-BOOST): a blinded, multicentre, randomised, controlled, phase 2 trial.
第一作者：
Alasdair P S,Munro
第一单位：
NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.
作者：
Alasdair P S,Munro [1]
;
Leila,Janani [2]
;
Victoria,Cornelius [2]
;
Parvinder K,Aley [3]
;
Gavin,Babbage [4]
;
David,Baxter [5]
;
Marcin,Bula [6]
;
Katrina,Cathie [1]
;
Krishna,Chatterjee [7]
;
Kate,Dodd [6]
;
Yvanne,Enever [8]
;
Karishma,Gokani [9]
;
Anna L,Goodman [10]
;
Christopher A,Green [9]
;
Linda,Harndahl [11]
;
John,Haughney [12]
;
Alexander,Hicks [11]
;
Agatha A,van der Klaauw [13]
;
Jonathan,Kwok [14]
;
Teresa,Lambe [3]
;
Vincenzo,Libri [15]
;
Martin J,Llewelyn [16]
;
Alastair C,McGregor [17]
;
Angela M,Minassian [18]
;
Patrick,Moore [19]
;
Mehmood,Mughal [5]
;
Yama F,Mujadidi [20]
;
Jennifer,Murira [21]
;
Orod,Osanlou [22]
;
Rostam,Osanlou [23]
;
Daniel R,Owens [1]
;
Mihaela,Pacurar [1]
;
Adrian,Palfreeman [24]
;
Daniel,Pan [24]
;
Tommy,Rampling [15]
;
Karen,Regan [25]
;
Stephen,Saich [4]
;
Jo,Salkeld [26]
;
Dinesh,Saralaya [25]
;
Sunil,Sharma [16]
;
Ray,Sheridan [27]
;
Ann,Sturdy [17]
;
Emma C,Thomson [28]
;
Shirley,Todd [27]
;
Chris,Twelves [21]
;
Robert C,Read [1]
;
Sue,Charlton [29]
;
Bassam,Hallis [29]
;
Mary,Ramsay [30]
;
Nick,Andrews [30]
;
Jonathan S,Nguyen-Van-Tam [31]
;
Matthew D,Snape [3]
;
Xinxue,Liu [20]
;
Saul N,Faust [32]
;
COV-BOOST study group
作者单位：
NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK.
[1]
Imperial Clinical Trials Unit, Imperial College London, London, UK.
[2]
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.
[3]
NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
[4]
Stockport NHS Foundation Trust, Stockport, UK.
[5]
NIHR Liverpool and Broadgreen Clinical Research Facility, Liverpool, UK.
[6]
NIHR Cambridge Clinical Research Facility, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
[7]
PHARMExcel, Welwyn Garden City, Hertfordshire, UK.
[8]
NIHR/Wellcome Clinical Research Facility, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
[9]
Department of Infection, Guy's and St Thomas' NHS Foundation Trust, London, UK; MRC Clinical Trials Unit, University College London, London, UK.
[10]
Portsmouth Hospitals University NHS Trust, Portsmouth, UK.
[11]
Queen Elizabeth University Hospital, NHS Greater Glasgow & Clyde, Glasgow, UK.
[12]
Wellcome-MRC Institute of Metabolic Science, Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK.
[13]
Cancer Research UK Oxford Centre, University of Oxford, Oxford, UK.
[14]
NIHR UCLH Clinical Research Facility and NIHR UCLH Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, UK.
[15]
University Hospitals Sussex NHS Foundation Trust, Brighton, UK.
[16]
Department of Infectious Diseases and Tropical Medicine, London Northwest University Healthcare, London, UK.
[17]
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
[18]
The Adam Practice, Poole, UK.
[19]
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
[20]
NIHR Leeds Clinical Research Facility, Leeds Teaching Hospitals Trust and University of Leeds, Leeds, UK.
[21]
North Wales Clinical Research Facility, Betsi Cadwaladr University Health Board and Bangor University, Bangor, UK.
[22]
Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
[23]
University Hospitals of Leicester NHS Trust, University of Leicester, Leicester, UK.
[24]
Bradford Institute for Health Research and Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK.
[25]
Department of Infection, Guy's and St Thomas' NHS Foundation Trust, London, UK.
[26]
Royal Devon and Exeter Hospital NHS Foundation Trust, Exeter, UK.
[27]
Queen Elizabeth University Hospital, NHS Greater Glasgow & Clyde, Glasgow, UK; MRC University of Glasgow Centre for Virus Research, Glasgow, UK.
[28]
UK Health Security Agency, Porton Down, UK.
[29]
UK Health Security Agency, Colindale, London, UK.
[30]
Division of Epidemiology and Public Health, University of Nottingham School of Medicine, Nottingham, UK.
[31]
NIHR Southampton Clinical Research Facility and Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton, UK. Electronic address: s.faust@soton.ac.uk.
[32]
医学主题词
成年人(Adult);老年人(Aged);老年人, 80以上(Aged, 80 and over);女(雌)性(Female);人类(Humans);免疫接种, 加强(Immunization, Secondary);男(雄)性(Male);中年人(Middle Aged);疾病大流行(Pandemics)
DOI
10.1016/S0140-6736(21)02717-3
PMID
34863358
发布时间
2025-05-30
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Lancet (London, England)
Lancet (London, England)
2258-2276页
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