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首页> Frontiers in immunology> Anti-TLR7 Antibody Protects Against Lupus Nephritis in NZBWF1 Mice by Targeting B Cells and Patrolling Monocytes.

Anti-TLR7 Antibody Protects Against Lupus Nephritis in NZBWF1 Mice by Targeting B Cells and Patrolling Monocytes.

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作者： Yusuke,Murakami ^[1] ; Ryutaro,Fukui ^[2] ; Reika,Tanaka ^[1] ; Yuji,Motoi ^[1] ; Atsuo,Kanno ^[1] ; Ryota,Sato ^[1] ; Kiyoshi,Yamaguchi ^[1] ; Hirofumi,Amano ^[3] ; Yoichi,Furukawa ^[4] ; Hitoshi,Suzuki ^[3] ; Yusuke,Suzuki ^[5] ; Naoto,Tamura ^[5] ; Naomi,Yamashita ^[4] ; Kensuke,Miyake ^[2]

作者单位： Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ^[1] Faculty of Pharmacy, Department of Pharmaceutical Sciences & Research Institute of Pharmaceutical Sciences, Musashino University, Tokyo, Japan. ^[2] Division of Clinical Genome Research, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ^[3] Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan. ^[4] Department of Nephrology, Juntendo University Faculty of Medicine, Tokyo, Japan. ^[5] Laboratory of Innate Immunity, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. ^[6]

关键词 autoantibody inhibitory monoclonal antibody lupus nephritis monocytes toll-like receptor

主题词动物(Animals);自身抗体(Autoantibodies);自身抗原(Autoantigens);自身免疫(Autoimmunity);B-淋巴细胞(B-Lymphocytes);疾病模型, 动物(Disease Models, Animal);疾病易感性(Disease Susceptibility);基因表达调控(Gene Expression Regulation);免疫球蛋白G(Immunoglobulin G);免疫组织化学(Immunohistochemistry);免疫表型分型(Immunophenotyping);狼疮肾炎(Lupus Nephritis);小鼠(Mice);单核细胞(Monocytes);Toll样受体7(Toll-Like Receptor 7)

DOI 10.3389/fimmu.2021.777197

PMID 34868046

发布时间 2022-02-10

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Frontiers in immunology

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