Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials.

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作者： Jill,Whitley ^[1] ; Christopher,Zwolinski ^[1] ; Christian,Denis ^[1] ; Maureen,Maughan ^[1] ; Leonie,Hayles ^[1] ; David,Clarke ^[1] ; Meghan,Snare ^[1] ; Hong,Liao ^[1] ; Sean,Chiou ^[1] ; Tina,Marmura ^[1] ; Holly,Zoeller ^[1] ; Ben,Hudson ^[1] ; John,Peart ^[1] ; Monica,Johnson ^[1] ; Amelia,Karlsson ^[1] ; Yunfei,Wang ^[1] ; Cynthia,Nagle ^[1] ; Cherell,Harris ^[1] ; Daniel,Tonkin ^[1] ; Stephanie,Fraser ^[1] ; Lieza,Capiz ^[1] ; Christina L,Zeno ^[1] ; Yvonne,Meli ^[1] ; Diana,Martik ^[1] ; Daniel A,Ozaki ^[1] ; Amy,Caparoni ^[1] ; Jason E,Dickens ^[1] ; Drew,Weissman ^[2] ; Kevin O,Saunders ^[1] ; Barton F,Haynes ^[1] ; Gregory D,Sempowski ^[1] ; Thomas N,Denny ^[3] ; Matthew R,Johnson ^[1]

作者单位： Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina. ^[1] Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. ^[2] Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina. Electronic address: thomas.denny@duke.edu. ^[3]

主题词动物(Animals);人类(Humans);RNA, 信使(RNA, Messenger);疫苗(Vaccines)

DOI 10.1016/j.trsl.2021.11.009

PMID 34871810

发布时间 2023-03-28

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Translational research

2022年242卷

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Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials.

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Development of mRNA manufacturing for vaccines and therapeutics: mRNA platform requirements and development of a scalable production process to support early phase clinical trials.

Translational research

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