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Coenzyme A fuels T cell anti-tumor immunity.

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第一作者： Michael,St Paul

第一单位： Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1C1, Canada.

作者： Michael,St Paul ^[1] ; Samuel D,Saibil ^[1] ; SeongJun,Han ^[1] ; Kavita,Israni-Winger ^[1] ; Scott C,Lien ^[1] ; Rob C,Laister ^[2] ; Azin,Sayad ^[2] ; Susanne,Penny ^[3] ; Rodabe N,Amaria ^[4] ; Lauren E,Haydu ^[5] ; Carlos R,Garcia-Batres ^[2] ; Meghan,Kates ^[1] ; David T,Mulder ^[2] ; Céline,Robert-Tissot ^[2] ; Matthew J,Gold ^[2] ; Charles W,Tran ^[1] ; Alisha R,Elford ^[2] ; Linh T,Nguyen ^[2] ; Trevor J,Pugh ^[2] ; Devanand M,Pinto ^[3] ; Jennifer A,Wargo ^[5] ; Pamela S,Ohashi ^[6]

作者单位： Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1C1, Canada. ^[1] Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada. ^[2] National Research Council, Human Health Therapeutics, Halifax, NS B3H 3Z1, Canada. ^[3] Department of Melanoma Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA. ^[4] Department of Surgical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA. ^[5] Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada; Department of Immunology, University of Toronto, Toronto, ON M5S 1C1, Canada. Electronic address: pohashi@uhnresearch.ca. ^[6]

关键词 CD8(+) T cells IL-22 Tc1 Tc17 Tc22 anti-PD1 coenzyme A immunometabolism immunotherapy pantothenate