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首页> Nature communications> Human miRNA miR-675 inhibits DUX4 expression and may be exploited as a potential treatment for Facioscapulohumeral muscular dystrophy.

Human miRNA miR-675 inhibits DUX4 expression and may be exploited as a potential treatment for Facioscapulohumeral muscular dystrophy.

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作者： Nizar Y,Saad ^[1] ; Mustafa,Al-Kharsan ^[1] ; Sara E,Garwick-Coppens ^[2] ; Gholamhossein Amini,Chermahini ^[1] ; Madison A,Harper ^[1] ; Andrew,Palo ^[1] ; Ryan L,Boudreau ^[1] ; Scott Q,Harper ^[3]

作者单位： Center for Gene Therapy, the Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. ^[1] Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. ^[2] Department of Internal Medicine, Fraternal Order of Eagles Diabetes Research Center, Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. ^[3] Center for Gene Therapy, the Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. scott.harper@nationwidechildrens.org. ^[4] Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA. scott.harper@nationwidechildrens.org. ^[5]

主题词成年人(Adult);老年人(Aged);动物(Animals);细胞死亡(Cell Death);疾病模型, 动物(Disease Models, Animal);药物释放系统(Drug Delivery Systems);女(雌)性(Female);基因表达调控(Gene Expression Regulation);HEK293细胞(HEK293 Cells);同源盒结构域蛋白质类(Homeodomain Proteins);人类(Humans);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);微RNAs(MicroRNAs);肌, 骨骼(Muscle, Skeletal);肌疾病(Muscular Diseases);肌营养不良, 面肩肱型(Muscular Dystrophy, Facioscapulohumeral);开放读码框架(Open Reading Frames);RNA干扰(RNA Interference)

DOI 10.1038/s41467-021-27430-1

PMID 34880230

发布时间 2023-02-09

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Nature communications

Nature communications

2021年12卷1期

7128页

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Nature communications

2021年12卷1期

7128页

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