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PI(3,4)P2-mediated cytokinetic abscission prevents early senescence and cataract formation.

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第一作者: Federico,Gulluni
第一单位: Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy.
作者单位: Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin 10126, Italy. [1] Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Praha, Czech Republic. [2] Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany. [3] Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA. [4] Department of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44106, USA. [5] Dipartimento di Scienze del Farmaco, Università degli Studi del Piemonte Orientale, "A. Avogadro", Largo Donegani 2, 28100 Novara, Italy. [6] Department of Nephrology and Hypertension, Friedrich-Alexander University Erlangen Nürnberg, Erlangen, Germany. [7] Section des Sciences Pharmaceutiques, University of Geneva, 1211 Geneva, Switzerland.;Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva, Switzerland. [8] Medical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. [9] Institute for Research in Biomedicine, Università della Svizzera Italiana, Bellinzona, Switzerland. [10] Pharmaceutical Biology, Lexicon Pharmaceuticals, The Woodlands, TX 77381, USA. [11] Division of Nephrology and Internal Intensive Care Medicine, Charite University, Berlin, Germany. [12] Section on Molecular Signal Transduction, Program for Developmental Neuroscience, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, MD 20892, USA. [13] Division of Pediatric Endocrinology, Ruth Children's Hospital, Rambam Medical Center, Haifa 30196, Israel.;The Genetics Institute, Rambam Health Care Campus, Haifa, Israel.;Rappaport Family Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 30196, Israel. [14] Division of Pediatric Endocrinology, Ruth Children's Hospital, Rambam Medical Center, Haifa 30196, Israel.;Rappaport Family Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 30196, Israel. [15] Department of Otolaryngology-Head and Neck Surgery, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.;Freie Universität Berlin, Faculty of Biology, Chemistry and Pharmacy, 14195 Berlin, Germany. [16] Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.;Freie Universität Berlin, Faculty of Biology, Chemistry and Pharmacy, 14195 Berlin, Germany. [17] Department of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA.;Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA. [18]
DOI 10.1126/science.abk0410
PMID 34882480
发布时间 2024-06-12
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