Structural Modelling of KCNQ1 and KCNH2 Double Mutant Proteins, Identified in Two Severe Long QT Syndrome Cases, Reveals New Insights into Cardiac Channelopathies.

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作者： William A,Agudelo ^[1] ; Sebastian Ramiro,Gil-Quiñones ^[2] ; Alejandra,Fonseca ^[2] ; Alvaro,Arenas ^[3] ; Laura,Castro ^[3] ; Diana Carolina,Sierra-Díaz ^[4] ; Manuel A,Patarroyo ^[1] ; Paul,Laissue ^[5] ; Carlos F,Suárez ^[6] ; Rodrigo,Cabrera ^[4]

作者单位： Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá 111221, Colombia. ^[1] Laboratorio de Biología Molecular y Pruebas Diagnósticas de Alta Complejidad, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá 111221, Colombia. ^[2] Department of Pediatric Electrophysiology, Congenital Heart Institute, Fundación Cardioinfantil-Instituto de Cardiología, Bogotá 111221, Colombia. ^[3] Center for Research in Genetics and Genomics (CIGGUR), GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Bogotá 111221, Colombia. ^[4] Health Sciences Division, Main Campus, Universidad Santo Tomás, Bogotá 111221, Colombia. ^[5] Microbiology Department, Faculty of Medicine, Universidad Nacional de Colombia, Bogotá 111221, Colombia. ^[6] Orphan Diseases Unit, Biopas Laboratories, BIOPAS Group, Bogotá 111221, Colombia. ^[7]

关键词 KCNH2 KCNQ1 cardiac channelopathies-computational modelling long QT syndrome