GSK-3 Inhibition Is Cytotoxic in Glioma Stem Cells through Centrosome Destabilization and Enhances the Effect of Radiotherapy in Orthotopic Models.

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作者： Anke,Brüning-Richardson ^[1] ; Gary C,Shaw ^[1] ; Daniel,Tams ^[1] ; Tim,Brend ^[1] ; Hitesh,Sanganee ^[2] ; Simon T,Barry ^[3] ; Gregory,Hamm ^[4] ; Richard J A,Goodwin ^[4] ; John G,Swales ^[4] ; Henry,King ^[1] ; Lynette,Steele ^[1] ; Ruth,Morton ^[1] ; Anastasia,Widyadari ^[1] ; Thomas A,Ward ^[1] ; Filomena,Esteves ^[1] ; Marjorie,Boissinot ^[1] ; Georgia,Mavria ^[1] ; Alastair,Droop ^[5] ; Sean E,Lawler ^[6] ; Susan C,Short ^[1]

作者单位： Leeds Institute of Medical Research at St James's, University of Leeds, Leeds LS9 7TF, UK. ^[1] Discovery Sciences BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 8PA, UK. ^[2] Bioscience, Early Oncology, Oncology R&D, AstraZeneca, Cambridge CB2 8PA, UK. ^[3] Imaging and Data Analytics, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 8PA, UK. ^[4] Leeds MRC Medical Bioinformatics Centre, University of Leeds, Leeds LS9 7TF, UK. ^[5] Brown University Cancer Center, Pathology & Laboratory Medicine, Brown University, Providence, RI 02903, USA. ^[6]

关键词 GSK-3 centrosome cytotoxicity glioblastoma radiation

DOI 10.3390/cancers13235939

PMID 34885051

发布时间 2024-02-10

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