Stable warfarin dose prediction in sub-Saharan African patients: A machine-learning approach and external validation of a clinical dose-initiation algorithm.

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第一作者： Innocent G,Asiimwe

第一单位： Department of Pharmacology and Therapeutics, The Wolfson Centre for Personalized Medicine, Medical Research Council Centre for Drug Safety Science, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.

作者： Innocent G,Asiimwe ^[1] ; Marc,Blockman ^[2] ; Karen,Cohen ^[2] ; Clint,Cupido ^[3] ; Claire,Hutchinson ^[1] ; Barry,Jacobson ^[4] ; Mohammed,Lamorde ^[5] ; Jennie,Morgan ^[6] ; Johannes P,Mouton ^[2] ; Doreen,Nakagaayi ^[7] ; Emmy,Okello ^[7] ; Elise,Schapkaitz ^[8] ; Christine,Sekaggya-Wiltshire ^[5] ; Jerome R,Semakula ^[5] ; Catriona,Waitt ^[9] ; Eunice J,Zhang ^[1] ; Andrea L,Jorgensen ^[10] ; Munir,Pirmohamed ^[1]

作者单位： Department of Pharmacology and Therapeutics, The Wolfson Centre for Personalized Medicine, Medical Research Council Centre for Drug Safety Science, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK. ^[1] Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa. ^[2] Victoria Hospital Internal Medicine Research Initiative, Victoria Hospital Wynberg, Cape Town, South Africa.;Department of Medicine, University of Cape Town, Cape Town, South Africa. ^[3] Department of Molecular Medicine and Haematology, University of the Witwatersrand, Johannesburg, South Africa. ^[4] Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda. ^[5] Metro District Health Services, Western Cape Department of Health, Cape Town, South Africa. ^[6] Uganda Heart Institute, Kampala, Uganda. ^[7] Department of Molecular Medicine and Hematology, Charlotte Maxeke Johannesburg Academic Hospital National Health Laboratory System Complex and University of Witwatersrand, Johannesburg, South Africa. ^[8] Department of Pharmacology and Therapeutics, The Wolfson Centre for Personalized Medicine, Medical Research Council Centre for Drug Safety Science, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.;Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda. ^[9] Department of Health Data Science, Institute of Population Health Sciences, University of Liverpool, Liverpool, UK. ^[10]

主题词成年人(Adult);撒哈拉沙漠以南非洲(Africa South of the Sahara);年龄因素(Age Factors);算法(Algorithms);抗凝药(Anticoagulants);体重(Body Weight);药物剂量计算(Drug Dosage Calculations);女(雌)性(Female);HIV感染(HIV Infections);人类(Humans);国际标准化比(International Normalized Ratio);男(雄)性(Male);中年人(Middle Aged);模型, 生物学(Models, Biological);结果可重复性(Reproducibility of Results);性别因素(Sex Factors);斯伐他汀(Simvastatin);华法林(Warfarin)

DOI 10.1002/psp4.12740

PMID 34889080

发布时间 2022-03-22

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CPT: pharmacometrics & systems pharmacology

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2022年11卷1期

20-29页

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Stable warfarin dose prediction in sub-Saharan African patients: A machine-learning approach and external validation of a clinical dose-initiation algorithm.

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Stable warfarin dose prediction in sub-Saharan African patients: A machine-learning approach and external validation of a clinical dose-initiation algorithm.

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