pH-Dependent supersaturation from amorphous solid dispersions of weakly basic drugs.

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作者： Bo,Wang ^[1] ; Matthew J,Nethercott ^[2] ; Akshay,Narula ^[3] ; Michael,Hanrahan ^[2] ; Shanming,Kuang ^[4] ; Robert M,Wenslow ^[5] ; Na,Li ^[6]

作者单位： Pharmaceutical Development, Biogen, 115 Broadway, Cambridge, Massachusetts, 02142, USA. ^[1] Kansas Analytical Services LLC, Fort Collins, 4921 Eagle Lake Drive, Ft. Collins, Colorado, 80524, USA. ^[2] Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Road Unit 3092, Storrs, Connecticut, 06269, USA. ^[3] Center for Pharma Crystallization, J-Star Research, 6 Cedarbrook Dr., Cranbury, New Jersey, 08512, USA. ^[4] Research and Development, Crystal Pharmatech Inc., 3000 Eastpark Blvd Suite 500B, Cranbury, New Jersey, 08512, USA. ^[5] Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Road Unit 3092, Storrs, Connecticut, 06269, USA. lina@uconn.edu. ^[6]

关键词 dissolution drug-polymer interactions enteric polymer ionization solubility suppression

主题词溶解度(Solubility);聚合物(Polymers);药物调剂(Drug Compounding)

DOI 10.1007/s11095-021-03147-0

PMID 34890018

发布时间 2022-11-07

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