作者:
Srivatsan,Raghavan [1]
;
Peter S,Winter [2]
;
Andrew W,Navia [3]
;
Hannah L,Williams [4]
;
Alan,DenAdel [5]
;
Kristen E,Lowder [6]
;
Jennyfer,Galvez-Reyes [7]
;
Radha L,Kalekar [6]
;
Nolawit,Mulugeta [7]
;
Kevin S,Kapner [6]
;
Manisha S,Raghavan [6]
;
Ashir A,Borah [8]
;
Nuo,Liu [7]
;
Sara A,Väyrynen [4]
;
Andressa Dias,Costa [4]
;
Raymond W S,Ng [6]
;
Junning,Wang [9]
;
Emma K,Hill [9]
;
Dorisanne Y,Ragon [9]
;
Lauren K,Brais [9]
;
Alex M,Jaeger [10]
;
Liam F,Spurr [6]
;
Yvonne Y,Li [6]
;
Andrew D,Cherniack [11]
;
Matthew A,Booker [12]
;
Elizabeth F,Cohen [12]
;
Michael Y,Tolstorukov [12]
;
Isaac,Wakiro [9]
;
Asaf,Rotem [13]
;
Bruce E,Johnson [14]
;
James M,McFarland [8]
;
Ewa T,Sicinska [15]
;
Tyler E,Jacks [10]
;
Ryan J,Sullivan [16]
;
Geoffrey I,Shapiro [17]
;
Thomas E,Clancy [18]
;
Kimberly,Perez [17]
;
Douglas A,Rubinson [17]
;
Kimmie,Ng [17]
;
James M,Cleary [17]
;
Lorin,Crawford [19]
;
Scott R,Manalis [20]
;
Jonathan A,Nowak [21]
;
Brian M,Wolpin [17]
;
William C,Hahn [1]
;
Andrew J,Aguirre [22]
;
Alex K,Shalek [23]
作者单位:
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
[1]
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: pswinter@mit.edu.
[2]
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
[3]
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.
[4]
Center for Computational Molecular Biology, Brown University, Providence, RI 02912, USA; Division of Applied Mathematics, Brown University, Providence, RI 02912, USA.
[5]
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
[6]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
[7]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
[8]
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
[9]
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
[10]
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA.
[11]
Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
[12]
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
[13]
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
[14]
Harvard Medical School, Boston, MA 02115, USA; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
[15]
Harvard Medical School, Boston, MA 02115, USA; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
[16]
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
[17]
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA.
[18]
Center for Computational Molecular Biology, Brown University, Providence, RI 02912, USA; Department of Biostatistics, Brown University, Providence, RI 02912, USA; Microsoft Research New England, Cambridge, MA 02142, USA.
[19]
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
[20]
Harvard Medical School, Boston, MA 02115, USA; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
[21]
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: andrew_aguirre@dfci.harvard.edu.
[22]
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address: shalek@mit.edu.
[23]
主题词
成年人(Adult);老年人(Aged);癌, 胰腺管(Carcinoma, Pancreatic Ductal);细胞系, 肿瘤(Cell Line, Tumor);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);男(雄)性(Male);中年人(Middle Aged);胰腺肿瘤(Pancreatic Neoplasms);单细胞分析(Single-Cell Analysis);肿瘤微环境(Tumor Microenvironment)
DOI
10.1016/j.cell.2021.11.017
PMID
34890551
发布时间
2024-06-07
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Cell
Cell
6119-6137.e26页
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