The N-terminal cysteine is a dual sensor of oxygen and oxidative stress.

导出 OA

翻译打印收藏纠错

作者： Ah Jung,Heo ^[1] ; Su Bin,Kim ^[2] ; Chang Hoon,Ji ^[3] ; Dohyun,Han ^[1] ; Su Jin,Lee ^[2] ; Su Hyun,Lee ^[1] ; Min Ju,Lee ^[2] ; Ji Su,Lee ^[3] ; Aaron,Ciechanover ^[4] ; Bo Yeon,Kim ^[1] ; Yong Tae,Kwon ^[2]

作者单位： Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul 03080, Korea. ^[1] Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Korea. ^[2] AUTOTAC Bio Inc., Jongno-gu, Seoul 03077, Korea. ^[3] Transdisciplinary Department of Medicine & Advanced Technology, Seoul National University Hospital, Seoul 03082, Korea. ^[4] The Rappaport Family Technion Integrated Cancer Center, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3109601, Israel. ^[5] World Class Institute, Anticancer Agents Research Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon 28116, Korea; bykim@kribb.re.kr yok5@snu.ac.kr. ^[6] Cellular Degradation Biology Center, College of Medicine, Seoul National University, Seoul 03080, Korea; bykim@kribb.re.kr yok5@snu.ac.kr. ^[7] Ischemic/Hypoxic Disease Institute, College of Medicine, Seoul National University, Seoul 03080, Korea. ^[8]

关键词 Arg/N-degron pathway Cys/N-degron pathway N-degron pathway oxidative stress sensor oxygen sensor