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Comparison of Predictions by BCS, rDCS and Machine Learning for the Effect of Food on Oral Drug Absorption Based on Features Calculated In silico.

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第一作者： Yusuke,Hoshino

第一单位： Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8675, Japan.;Toxicology & Pharmacokinetics Research, Central Research Laboratories, Zeria Pharmaceutical Co., Ltd, 2512-1 Numagami, Oshikiri, Kumagaya-shi, Saitama, 360-0111, Japan.

作者： Yusuke,Hoshino ^[1] ; Hideki,Yoshioka ^[2] ; Akihiro,Hisaka ^[3]

作者单位： Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8675, Japan.;Toxicology & Pharmacokinetics Research, Central Research Laboratories, Zeria Pharmaceutical Co., Ltd, 2512-1 Numagami, Oshikiri, Kumagaya-shi, Saitama, 360-0111, Japan. ^[1] Department of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba-shi, Ibaraki, 305-8575, Japan. ^[2] Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba-shi, Chiba, 260-8675, Japan. hisaka@chiba-u.jp. ^[3]

关键词 Biopharmaceutics Classification System Food effect In silico Machine learning Refined Developability Classification System

医学主题词生物药学(Biopharmaceutics);药物发现(Drug Discovery);肠吸收(Intestinal Absorption);通透性(Permeability);溶解度(Solubility)

DOI 10.1208/s12248-021-00664-z

PMID 34893922

发布时间 2022-04-05

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