TIMELAPSE study-efficacy of low-dose amitriptyline versus cognitive behavioral therapy for chronic insomnia in patients with medical comorbidity: study protocol of a randomized controlled multicenter non-inferiority trial.

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作者： Nynke L,Rauwerda ^[1] ; Hans,Knoop ^[2] ; Irene,Pot ^[3] ; Annemieke,van Straten ^[4] ; Marian E,Rikkert ^[5] ; Anouk,Zondervan ^[6] ; Thom P J,Timmerhuis ^[7] ; Annemarie M J,Braamse ^[8] ; H Myrthe,Boss ^[3]

作者单位： Department of Medical Psychology, Hospital Gelderse Vallei, Ede, The Netherlands. rauwerdan@zgv.nl. ^[1] Department of Medical Psychology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands. rauwerdan@zgv.nl. ^[2] Department of Medical Psychology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands. ^[3] Department of Medical Psychology, Hospital Gelderse Vallei, Ede, The Netherlands. ^[4] Department of Clinical Psychology & Amsterdam Public Health Research Institute, VU University, Amsterdam, The Netherlands. ^[5] Department of Medical Psychology, Hospital Rivierenland, Tiel, The Netherlands. ^[6] Department of Medical Psychology, Zaans Medical Center, Zaandam, The Netherlands. ^[7] Department of Neurology, Jeroen Bosch Ziekenhuis, 's-Hertogenbosch, the Netherlands. ^[8] Department of Neurology, Hospital Gelderse Vallei, Ede, The Netherlands. ^[9]

关键词 Amitriptyline CBT-I Cognitive behavioral therapy Fatigue Insomnia Medical comorbidity Non-inferiority Pain Treatment preference