Neutralization of Typhoid Toxin by Alpaca-Derived, Single-Domain Antibodies Targeting the PltB and CdtB Subunits.

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第一作者： Hari P,Dulal

第一单位： Department of Microbiology and Immunology, Cornell Universitygrid.5386.8, Ithaca, New York, USA.

作者： Hari P,Dulal ^[1] ; David J,Vance ^[2] ; Durga P,Neupane ^[1] ; Xiangcheng,Chen ^[2] ; Jacqueline M,Tremblay ^[3] ; Charles B,Shoemaker ^[3] ; Nicholas J,Mantis ^[2] ; Jeongmin,Song ^[1]

作者单位： Department of Microbiology and Immunology, Cornell Universitygrid.5386.8, Ithaca, New York, USA. ^[1] Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA. ^[2] Department of Infectious Diseases and Global Health, Tufts Universitygrid.429997.8, North Grafton, Massachusetts, USA. ^[3]

关键词 S. Typhi VHH single-domain antibody antibody nanobody neutralizing antibodies toxin neutralization typhoid fever typhoid toxin

主题词动物(Animals);骆驼, 新大陆(Camelids, New World);内皮细胞(Endothelial Cells);小鼠(Mice);多糖类(Polysaccharides);伤寒沙门菌(Salmonella typhi);伤寒(Typhoid Fever)

DOI 10.1128/IAI.00515-21

PMID 34898253

发布时间 2022-04-20

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