换一批Discriminating between competing models for the allosteric regulation of oncogenic phosphatase SHP2 by characterizing its active state.
第一作者：
Paolo,Calligari
第一单位：
Dipartimento di Scienze e Tecnologie Chimiche, Università di Roma Tor Vergata, Rome, Italy.
作者：
关键词
BTLA, B and T lymphocyte attenuatorCTLA-4, cytotoxic T lymphocyte-associated antigen 4FRET, F?rster resonance energy transferInter-domain dynamicsJMML, juvenile myelomonocytic leukemiaMD, molecular dynamicsNS, Noonan syndromeNSML, Noonan syndrome with multiple lentiginesPD-1, programmed cell death protein 1PDB, protein data bankPMF, potential of mean forcePTP, protein tyrosine phosphataseProtein flexibilityREMD, replica exchange molecular dynamicsRMSD, root mean square deviationRMSF, root mean square fluctuationRTK, receptor tyrosine kinaseReplica exchange molecular dynamics simulationsSASA, solvent accessible surface areaSAXS, small angle X-ray scatteringSH2, Src homology 2SHP2 regulatory mechanismSHP2, Src homology 2 domain-containing phosphatase 2SIRPalpha, signal regulatory protein alphapY, phosphorylated tyrosine
DOI
10.1016/j.csbj.2021.10.041
PMID
34900129
发布时间
2024-04-04
- 浏览3
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
