换一批
换一批Gains from no real PAINS: Where 'Fair Trial Strategy' stands in the development of multi-target ligands.
第一作者：
Jianbo,Sun
第一单位：
State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
作者：
关键词
AD, Alzheimer diseaseALARM NMR, a La assay to detect reactive molecules by nuclear magnetic resonanceBiochemical experimentCADD, computer-aided drug design technologyCoA, coenzyme AEGFR, epidermal growth factor receptorFair trial strategyGSH, glutathioneHER2, human epidermal growth factor receptor 2HTS, high-throughput screeningIn silico filteringLC?MS, liquid chromatography?mass spectrometryMTDLs, multitarget-directed ligandsMultitarget-directed ligandsPAINS suspectsPAINS, pan-assay interference compoundsQSAR, quantitative structure–activity relationshipROS, radicals and oxygen reactive species
DOI
10.1016/j.apsb.2021.02.023
PMID
34900527
发布时间
2024-04-04
- 浏览0
Acta pharmaceutica Sinica. B
2021年11卷11期
3417-3432页
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
