换一批
第一作者：
Jürgen,Brem
第一单位：
Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK. jurgen.brem@chem.ox.ac.uk.
作者：
Jürgen,Brem [1]
;
Tharindi,Panduwawala [2]
;
Jon Ulf,Hansen [3]
;
Joanne,Hewitt [4]
;
Edgars,Liepins [5]
;
Pawel,Donets [5]
;
Laura,Espina [6]
;
Alistair J M,Farley [2]
;
Kirill,Shubin [5]
;
Gonzalo Gomez,Campillos [2]
;
Paula,Kiuru [7]
;
Shifali,Shishodia [8]
;
Daniel,Krahn [2]
;
Robert K,Leśniak [2]
;
Juliane,Schmidt Adrian [2]
;
Karina,Calvopiña [2]
;
María-Carmen,Turrientes [9]
;
Madeline E,Kavanagh [10]
;
Dmitrijs,Lubriks [5]
;
Philip,Hinchliffe [11]
;
Gareth W,Langley [12]
;
Ali F,Aboklaish [6]
;
Anders,Eneroth [13]
;
Maria,Backlund [13]
;
Andrei G,Baran [5]
;
Elisabet I,Nielsen [14]
;
Michael,Speake [15]
;
Janis,Kuka [5]
;
John,Robinson [15]
;
Solveiga,Grinberga [5]
;
Lindsay,Robinson [15]
;
Michael A,McDonough [2]
;
Anna M,Rydzik [16]
;
Thomas M,Leissing [2]
;
Juan Carlos,Jimenez-Castellanos [17]
;
Matthew B,Avison [11]
;
Solange,Da Silva Pinto [2]
;
Andrew D,Pannifer [4]
;
Marina,Martjuga [5]
;
Emma,Widlake [6]
;
Martins,Priede [5]
;
Iva,Hopkins Navratilova [4]
;
Marek,Gniadkowski [18]
;
Anna Karin,Belfrage [19]
;
Peter,Brandt [20]
;
Jari,Yli-Kauhaluoma [7]
;
Eric,Bacque [21]
;
Malcolm G P,Page [22]
;
Fredrik,Björkling [23]
;
Jonathan M,Tyrrell [24]
;
James,Spencer [11]
;
Pauline A,Lang [2]
;
Pawel,Baranczewski [25]
;
Rafael,Cantón [9]
;
Stuart P,McElroy [15]
;
Philip S,Jones [15]
;
Fernando,Baquero [9]
;
Edgars,Suna [5]
;
Angus,Morrison [15]
;
Timothy R,Walsh [6]
;
Christopher J,Schofield [26]
作者单位：
Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK. jurgen.brem@chem.ox.ac.uk.
[1]
Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.
[2]
Statens Serum Institut, Copenhagen, Denmark.
[3]
University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.
[4]
Latvian Institute of Organic Synthesis, Riga, Latvia.
[5]
Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK.
[6]
Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
[7]
Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.;Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA.
[8]
Department of Microbiology, Ramón y Cajal University Hospital and Ramón y Cajal Institute for Health Research (IRYCIS), Madrid, Spain.
[9]
Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.;Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA.
[10]
School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
[11]
Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.;Charles River Laboratories, Saffron Walden, UK.
[12]
Department of Pharmacy, Uppsala Drug Optimization and Pharmaceutical Profiling Platform (UDOPP), Uppsala University, Uppsala, Sweden.
[13]
Department of Pharmacy, Uppsala University, Uppsala, Sweden.
[14]
University of Dundee, European Screening Centre, BioCity Scotland, Newhouse, UK.;BioAscent Discovery Ltd, Newhouse, UK.
[15]
Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK.;Research and Early Development, Respiratory & Immunology, AstraZeneca, Mölndal, Sweden.
[16]
School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.;Chemical Biology of Antibiotics, Centre for Infection & Immunity (CIIL), Pasteur Institute, INSERM U1019 - CNRS UMR 9017, Lille, France.
[17]
Department of Molecular Microbiology, National Medicines Institute, Warsaw, Poland.
[18]
Department of Medicinal Chemistry, Drug Design and Discovery, Uppsala University, Uppsala, Sweden.
[19]
Department of Medicinal Chemistry, Drug Design and Discovery, Uppsala University, Uppsala, Sweden.;Beactica Therapeutics AB, Uppsala, Sweden.
[20]
Evotec Infectious Diseases Lyon, Marcy l'Etoile, France.
[21]
Jacobs University Bremen gGmbH, Bremen, Germany.
[22]
Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
[23]
Department of Medical Microbiology, Institute of infection & Immunity, Cardiff University, Cardiff, UK.;School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
[24]
Department of Pharmacy, SciLifeLab Drug Discovery and Development Platform, ADME of Therapeutics Facility, Uppsala University, Uppsala, Sweden.
[25]
Department of Chemistry, Chemistry Research Laboratory and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, Oxford, UK. christopher.schofield@chem.ox.ac.uk.
[26]
医学主题词
动物(Animals);革兰氏阴性菌(Gram-Negative Bacteria);人类(Humans);小鼠(Mice);微生物敏感性试验(Microbial Sensitivity Tests);蛋白质结合(Protein Binding);构效关系(Structure-Activity Relationship);β内酰胺类(beta-Lactams)
DOI
10.1038/s41557-021-00831-x
PMID
34903857
发布时间
2025-05-30
- 浏览1
Nature chemistry
Nature chemistry
15-24页
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
