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High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain.

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第一作者： Morgan,Dasovich

第一单位： Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, United States.;Department of Chemistry, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, Maryland 21218, United States.

作者： Morgan,Dasovich ^[1] ; Junlin,Zhuo ^[2] ; Jack A,Goodman ^[2] ; Ajit,Thomas ^[3] ; Robert Lyle,McPherson ^[2] ; Aravinth Kumar,Jayabalan ^[2] ; Veronica F,Busa ^[2] ; Shang-Jung,Cheng ^[2] ; Brennan A,Murphy ^[4] ; Karli R,Redinger ^[5] ; Yousef M O,Alhammad ^[6] ; Anthony R,Fehr ^[6] ; Takashi,Tsukamoto ^[3] ; Barbara S,Slusher ^[3] ; Jürgen,Bosch ^[7] ; Huijun,Wei ^[3] ; Anthony K L,Leung ^[2]

作者单位： Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, United States.;Department of Chemistry, Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, Maryland 21218, United States. ^[1] Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, United States. ^[2] Johns Hopkins Drug Discovery, Baltimore, Maryland 21205, United States.;Department of Neurology, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, United States. ^[3] Johns Hopkins Drug Discovery, Baltimore, Maryland 21205, United States. ^[4] Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio 44106, United States. ^[5] Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, United States. ^[6] Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio 44106, United States.;InterRayBio, LLC, Cleveland, Ohio 44106, United States. ^[7]

医学主题词抗病毒药(Antiviral Agents);高通量筛选分析(High-Throughput Screening Assays);N-糖基水解酶类(N-Glycosyl Hydrolases)

DOI 10.1021/acschembio.1c00721

PMID 34904435

发布时间 2024-06-08

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