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The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells.

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第一作者： Abel M,Mengeste

第一单位： Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Norway.

作者： Abel M,Mengeste ^[1] ; Jenny,Lund ^[1] ; Parmeshwar,Katare ^[1] ; Roya,Ghobadi ^[1] ; Hege G,Bakke ^[1] ; Per Kristian,Lunde ^[2] ; Lars,Eide ^[3] ; Gavin O',Mahony ^[4] ; Sven,Göpel ^[5] ; Xiao-Rong,Peng ^[5] ; Eili Tranheim,Kase ^[1] ; G Hege,Thoresen ^[6] ; Arild C,Rustan ^[1]

作者单位： Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Norway. ^[1] Institute for Experimental Medical Research, Oslo University Hospital and University of Oslo, Norway.;KG Jebsen Cardiac Research Centre, University of Oslo, Norway. ^[2] Department of Medical Biochemistry, Institute of Clinical Medicine, University of Oslo, Norway. ^[3] Medicinal Chemistry, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. ^[4] Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden. ^[5] Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Norway.;Department of Pharmacology, Institute of Clinical Medicine, University of Oslo, Norway. ^[6]

关键词 AMPK AMPK, AMP-activated protein kinase ASM, acid-soluble metabolites CE, cholesteryl ester DAG, diacylglycerol FA, fatty acid FCCP, 4-(trifluromethoxy)phenylhydrazone Glucose metabolism Lipid metabolism OA, oleic acid OCR, oxygen consumption rate Obesity SCD1, stearoyl-CoA desaturase 1 SERCA SERCA, sarco(endo)plasmic reticulum Ca2+-ATPase Skeletal muscle T2DM, type 2 diabetes mellitus Type 2 diabetes

DOI 10.1016/j.crphar.2021.100060

PMID 34909682

发布时间 2022-04-29

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The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells.

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