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A gene-centric approach to biomarker discovery identifies transglutaminase 1 as an epidermal autoantigen.

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作者单位: Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala 751 23, Sweden; nils.landegren@imbim.uu.se. [1] Center for Molecular Medicine, Department of Medicine (Solna), Karolinska Institutet, Stockholm 171 76, Sweden. [2] Department of Dermatology, Kurume University School of Medicine, Kurume 830-0111, Japan. [3] Dermatology Unit, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm 171 76, Sweden. [4] Department of Medical Sciences, Uppsala University 751 85, Sweden. [5] Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala 751 85, Sweden. [6] Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki 00014, Finland. [7] Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 171 76, Sweden. [8] Department of Clinical Genetics, Karolinska University Hospital, Stockholm 171 76, Sweden. [9] Folkhälsan Institute of Genetics, Helsinki 00290, Finland. [10] Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm 171 76, Sweden. [11] Department of Cell and Molecular Biology, Karolinska Institute, Solna 171 77, Sweden. [12] Dermatology Clinic, Karolinska University Hospital, Solna 171 76, Sweden. [13] Science for Life Laboratory, Department of Medicine (Solna), Karolinska Institutet, Stockholm 171 76, Sweden. [14] Division of Infectious Diseases, Karolinska University Hospital, Stockholm 171 76, Sweden. [15] Department of Women's Health, Uppsala University, Uppsala 751 85, Sweden. [16] Department of Children's Health, Uppsala University, Uppsala 751 85, Sweden. [17] Heim Pál National Paediatric Institute, Coeliac Disease Centre, Budapest 1089, Hungary. [18] Department of Paediatrics, University of Debrecen Medical Faculty, Debrecen 4032, Hungary. [19] The Diabetes and Celiac Disease Unit, Department of Clinical Sciences, Lund University, Lund 221 00, Sweden. [20] Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm 171 76, Sweden. [21] Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan. [22] K.G. Jebsen Center for Autoimmune Disorders, Department of Clinical Science, University of Bergen, Bergen NO-5020, Norway. [23]
DOI 10.1073/pnas.2100687118
PMID 34911754
发布时间 2022-01-22
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Proceedings of the National Academy of Sciences of the United States of America

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