An In vitro dimerization assay for the adverse outcome pathway approach in risk assessment of human estrogen receptor α-mediated endocrine-disrupting chemicals.

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第一作者： Seok-Hee,Lee

第一单位： Department of Food Science and Biotechnology, Dongguk University, Goyang, 10326, Republic of Korea.

作者： Seok-Hee,Lee ^[1] ; Huiwon,Seo ^[1] ; Hyeyeong,Seo ^[2] ; Maria,Lazari ^[3] ; Martin,D'Agostino ^[3] ; Nick,Byrd ^[4] ; Kyong Sup,Yoon ^[5] ; Hee-Seok,Lee ^[6] ; Yooheon,Park ^[7]

作者单位： Department of Food Science and Biotechnology, Dongguk University, Goyang, 10326, Republic of Korea. ^[1] Department of Integrated Biomedical and Life Science, Korea University, Seoul, 02841, Republic of Korea. ^[2] Department of Virology, Campden BRI, Chipping Campden, Gloucestershire, GL556LD, UK. ^[3] Department of Chemistry and Biochemistry, Campden BRI, Chipping Campden, Gloucestershire, GL556LD, UK. ^[4] Department of Environmental Sciences, Southern-Illinois University Edwardsville, Edwardsville, IL, 62026, USA. ^[5] Department of Food Science and Technology, Chung-Ang University, Anseong, 17546, Republic of Korea. Electronic address: hslee0515@cau.ac.kr. ^[6] Department of Food Science and Biotechnology, Dongguk University, Goyang, 10326, Republic of Korea. Electronic address: ypark@dongguk.edu. ^[7]

关键词 Adverse outcome pathway (AOP)Bioluminescence resonance energy transfer (BRET)Chemical risk assessment Estrogen receptor α (ERα)In vitro dimerization assay

主题词二聚作用(Dimerization);内分泌干扰物(Endocrine Disruptors);能量传递(Energy Transfer);雌激素受体α(Estrogen Receptor alpha);人类(Humans)

DOI 10.1016/j.chemosphere.2021.133267

PMID 34914963

发布时间 2022-01-20

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