Postoperative radiotherapy versus no postoperative radiotherapy in patients with completely resected non-small-cell lung cancer and proven mediastinal N2 involvement (Lung ART): an open-label, randomised, phase 3 trial.
作者:
Cecile,Le Pechoux [1]
;
Nicolas,Pourel [2]
;
Fabrice,Barlesi [3]
;
Delphine,Lerouge [4]
;
Delphine,Antoni [5]
;
Bruno,Lamezec [6]
;
Ursula,Nestle [7]
;
Pierre,Boisselier [8]
;
Eric,Dansin [9]
;
Amaury,Paumier [10]
;
Karine,Peignaux [11]
;
François,Thillays [12]
;
Gerard,Zalcman [13]
;
Jeannick,Madelaine [14]
;
Eric,Pichon [15]
;
Anne,Larrouy [16]
;
Armelle,Lavole [17]
;
Delphine,Argo-Leignel [18]
;
Marc,Derollez [19]
;
Corinne,Faivre-Finn [20]
;
Matthew Q,Hatton [21]
;
Oliver,Riesterer [22]
;
Emilie,Bouvier-Morel [23]
;
Ariane,Dunant [23]
;
John G,Edwards [24]
;
Pascal Alexandre,Thomas [25]
;
Olaf,Mercier [26]
;
Aurelie,Bardet [27]
作者单位:
Department of Radiation Oncology, Gustave Roussy, Villejuif, France. Electronic address: cecile.lepechoux@gustaveroussy.fr.
[1]
Radiation Oncology, Institut Sainte Catherine, Avignon, France.
[2]
Department of Medical Oncology, Gustave Roussy, Villejuif, France; Aix-Marseille University, Centre National de la Recherche Scientifique, Institut National des Sciences et de la Recherche Médicale, Centre de Recherche en Cancérologie de Marseille, Assistance Publique - Hôpitaux de Marseille, Marseille, France.
[3]
Department of Radiation Oncology, Centre Baclesse, Caen, France.
[4]
Department of Radiation Oncology, Centre Paul Strauss, Strasbourg, France.
[5]
Radiation Oncology, Centre Armoricain de Radiothérapie, d'Imagerie médicale et d'Oncologie, St Brieuc, France.
[6]
Department of Radiation Oncology, University Hospital Freiburg, Freiburg, Germany; Department of Radiation Oncology, Kliniken Maria Hilf, Moenchengladbach, Germany.
[7]
Department of Radiation Oncology, Centre Val d'Aurelle, Montpellier, France.
[8]
Department of Medical Oncology, Centre Oscar Lambret, Lille, France.
[9]
Department of Radiation Oncology, Institut de cancérologie de l'Ouest Centre Paul Papin, Angers, France.
[10]
Department of Radiation Oncology, Centre Georges-Francois Leclerc, Dijon, France.
[11]
Department of Radiation Oncology, Institut de Cancérologie de l'Ouest Centre René Gauducheau, Nantes, France.
[12]
Department of Pneumology, Centre Hospitalier Universitaire de Caen, Caen, France; Department of Thoracic Oncology, Université de Paris, Centre d'Investigation Clinique-1425-Bichat-Claude Bernard Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.
[13]
Department of Pneumology, Centre Hospitalier Universitaire de Caen, Caen, France.
[14]
Department of Pneumology, Centre Hospitalier Universitaire de Tours, Tours, France.
[15]
Radiation Oncology, Centre Specialisé Cancerologie Paris Nord, Sarcelles, France.
[16]
Department of Thoracic Oncology, Tenon University Hospital, Assistance Publique-Hopitaux de Paris, Paris, France.
[17]
Radiation Oncology, Centre Hospitalier de Bretagne Sud, Lorient, France.
[18]
Pneumology, Polyclinique du Val de Sambre, Maubeuge, France.
[19]
University of Manchester and The Christie NHS Foundation Trust, Manchester, UK.
[20]
Department of Clinical Oncology, Weston Park Hospital, Sheffield, UK.
[21]
Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich and Centre for Radiation Oncology, Cantonal Hospitals Aarau and Baden, Aarau, Switzerland.
[22]
International Center for Thoracic Cancers, and Department of Biostatistics and Epidemiology, Gustave Roussy, Villejuif, France.
[23]
Department of Cardiothoracic Surgery, Northern General Hospital, Sheffield, UK.
[24]
Department of Thoracic Surgery, Hôpital Nord, Assistance Publique-Hopitaux de Marseille, Aix-Marseille University, Marseille, France.
[25]
Department of Thoracic and Vascular Surgery and Heart-Lung Transplantation, Institut d'Oncologie Thoracique, Marie-Lannelongue Hospital, Paris-Saclay University, Le Plessis Robinson, France.
[26]
International Center for Thoracic Cancers, and Department of Biostatistics and Epidemiology, Gustave Roussy, Villejuif, France; Oncostat Unité Mixte de Recherche 1018, Inserm, University Paris-Saclay, labeled Ligue Contre le Cancer, Villejuif, France.
[27]
主题词
老年人(Aged);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);综合疗法(Combined Modality Therapy);女(雌)性(Female);人类(Humans);肺肿瘤(Lung Neoplasms);男(雄)性(Male);纵隔(Mediastinum);中年人(Middle Aged);肿瘤分期(Neoplasm Staging);放射疗法, 调强适形(Radiotherapy, Intensity-Modulated)
DOI
10.1016/S1470-2045(21)00606-9
PMID
34919827
发布时间
2024-03-20
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The Lancet. Oncology
The Lancet. Oncology
104-114页
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