Modulating physicochemical properties of tetrahydropyridine-2-amine BACE1 inhibitors with electron-withdrawing groups: A systematic study.

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作者： Frederik J R,Rombouts ^[1] ; Chien-Chi,Hsiao ^[2] ; Solène,Bache ^[2] ; Michel,De Cleyn ^[2] ; Pauline,Heckmann ^[2] ; Jos,Leenaerts ^[2] ; Carolina,Martinéz-Lamenca ^[2] ; Sven,Van Brandt ^[2] ; Aldo,Peschiulli ^[2] ; Ann,Vos ^[2] ; Harrie J M,Gijsen ^[2]

作者单位： Janssen Research & Development, Turnhoutseweg 30, B-2340, Beerse, Belgium. Electronic address: frombout@its.jnj.com. ^[1] Janssen Research & Development, Turnhoutseweg 30, B-2340, Beerse, Belgium. ^[2]

关键词 Alzheimer's Amidine BACE1 EPSA logD pK(a)

主题词脒类(Amidines);淀粉样前体蛋白分泌酶类(Amyloid Precursor Protein Secretases);动物(Animals);天冬氨酸内肽酶类(Aspartic Acid Endopeptidases);化学, 物理(Chemistry, Physical);狗(Dogs);剂量效应关系, 药物(Dose-Response Relationship, Drug);电子(Electrons);酶抑制剂(Enzyme Inhibitors);人类(Humans);分子结构(Molecular Structure);吡咯烷类(Pyrrolidines);构效关系(Structure-Activity Relationship)

DOI 10.1016/j.ejmech.2021.114028

PMID 34920170

发布时间 2022-01-26

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European journal of medicinal chemistry

2022年228卷

114028页

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Modulating physicochemical properties of tetrahydropyridine-2-amine BACE1 inhibitors with electron-withdrawing groups: A systematic study.

European journal of medicinal chemistry

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European journal of medicinal chemistry

相关期刊

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Modulating physicochemical properties of tetrahydropyridine-2-amine BACE1 inhibitors with electron-withdrawing groups: A systematic study.

European journal of medicinal chemistry

相似文献

European journal of medicinal chemistry

相关期刊

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