In vitro and in silico studies of fluorinated 2,3-disubstituted thiazolidinone-pyrazoles as potential α-amylase inhibitors and antioxidant agents.

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作者： Devaraj,Ganavi ^[1] ; Ramith,Ramu ^[2] ; Vasantha,Kumar ^[3] ; Shashank M,Patil ^[2] ; Reshma M,Martiz ^[3] ; Prithvi S,Shirahatti ^[3] ; Reshma,Sathyanarayana ^[4] ; Boja,Poojary ^[1] ; B Shivarama,Holla ^[1] ; Vishwanatha,Poojary ^[2] ; K P Nanda,Kumari ^[2] ; Jagadeep Chandra,Shivachandra ^[2]

作者单位： Department of Studies and Research in Chemistry, Mangalore University, Mangalagangothri, India. ^[1] Department of Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire, India. ^[2] Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. ^[3] Department of Biotechnology, Teresian College, Mysuru, Karnataka, India. ^[4] Department of Microbiology, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. ^[5]

关键词 antioxidant enzyme kinetics molecular docking pyrazole aldehydes thiazolidin-4-ones α-amylase inhibition

主题词抗氧化剂(Antioxidants);吡唑类(Pyrazoles);构效关系(Structure-Activity Relationship);α淀粉酶类(alpha-Amylases)

DOI 10.1002/ardp.202100342

PMID 34923670

发布时间 2022-05-31

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