Generation of three human induced pluripotent stem cell lines with IRX5 knockout and knockin genetic editions using CRISPR-Cas9 system.

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第一作者： Robin,Canac

第一单位： Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France.

作者： Robin,Canac ^[1] ; Amandine,Caillaud ^[1] ; Bastien,Cimarosti ^[1] ; Aurore,Girardeau ^[1] ; Hanan,Hamamy ^[2] ; Bruno,Reversade ^[3] ; Carine,Bonnard ^[4] ; Zeina R,Al Sayed ^[1] ; Laurent,David ^[5] ; Jeremie,Poschmann ^[6] ; Patricia,Lemarchand ^[1] ; Guillaume,Lamirault ^[1] ; Nathalie,Gaborit ^[7]

作者单位： Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France. ^[1] Department of Genetic Medicine and Development, Geneva University, Geneva 1211, Switzerland. ^[2] Genome Institute of Singapore, A*STAR, Singapore, Singapore; Medical Genetics Department, Koç University School of Medicine (KUSOM), Istanbul, Turkey; Department of Paediatrics, National, University of Singapore, Singapore, Singapore; Institute of Molecular and Cell Biology, A*STAR, Singapore, Singapore; Reproductive Biology Laboratory, Amsterdam UMC, Amsterdam-Zuidoost, the Netherlands. ^[3] Skin Research Institute of Singapore, A*STAR, Singapore, Singapore. ^[4] Université de Nantes, CHU Nantes, INSERM, CNRS, SFR Santé, FED 4203, INSERM UMS 016, CNRS, UMS 3556, F-44000 Nantes, France; Université de Nantes, CHU Nantes, INSERM, CRTI, UMR 1064, ITUN, F-44000 Nantes, France. ^[5] Université de Nantes, CHU Nantes, INSERM, CRTI, UMR 1064, ITUN, F-44000 Nantes, France. ^[6] Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France. Electronic address: nathalie.gaborit@univ-nantes.fr. ^[7]

主题词动物(Animals);杂合子(Heterozygote);同源盒结构域蛋白质类(Homeodomain Proteins);纯合子(Homozygote);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);肌细胞, 心脏(Myocytes, Cardiac);转录因子(Transcription Factors)

DOI 10.1016/j.scr.2021.102627

PMID 34929443

发布时间 2022-04-15

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Stem cell research

2022年58卷

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Generation of three human induced pluripotent stem cell lines with IRX5 knockout and knockin genetic editions using CRISPR-Cas9 system.

Stem cell research

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Generation of three human induced pluripotent stem cell lines with IRX5 knockout and knockin genetic editions using CRISPR-Cas9 system.

Stem cell research

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Stem cell research

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