Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
作者:
主题词
抗肿瘤药(Antineoplastic Agents);联苄类(Bibenzyls);癌, 肝细胞(Carcinoma, Hepatocellular);细胞增殖(Cell Proliferation);链接化学(Click Chemistry);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);肝肿瘤(Liver Neoplasms);氧化性应激(Oxidative Stress);酚(Phenol);丙酮酸羧化酶(Pyruvate Carboxylase);构效关系(Structure-Activity Relationship)
DOI
10.1021/acs.jmedchem.1c01605
PMID
34931827
发布时间
2022-02-07
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Journal of medicinal chemistry
460-484页
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