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High-Throughput Screening Campaign Identified a Potential Small Molecule RXFP3/4 Agonist.

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第一作者： Guangyao,Lin

第一单位： The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;University of Chinese Academy of Sciences, Beijing 100049, China.

作者： Guangyao,Lin ^[1] ; Yang,Feng ^[2] ; Xiaoqing,Cai ^[2] ; Caihong,Zhou ^[2] ; Lijun,Shao ^[3] ; Yan,Chen ^[4] ; Linhai,Chen ^[2] ; Qing,Liu ^[2] ; Qingtong,Zhou ^[4] ; Ross A D,Bathgate ^[5] ; Dehua,Yang ^[6] ; Ming-Wei,Wang ^[7]

作者单位： The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;University of Chinese Academy of Sciences, Beijing 100049, China. ^[1] The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ^[2] University of Chinese Academy of Sciences, Beijing 100049, China.;School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China. ^[3] Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China. ^[4] Florey Institute of Neuroscience and Mental Health and Department of Biochemistry and Pharmacology, The University of Melbourne, Parkville, VIC 3052, Australia. ^[5] The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;University of Chinese Academy of Sciences, Beijing 100049, China.;The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;Research Center for Deepsea Bioresources, Sanya 572025, Hainan, China. ^[6] The National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;University of Chinese Academy of Sciences, Beijing 100049, China.;School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.;Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.;The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.;Research Center for Deepsea Bioresources, Sanya 572025, Hainan, China. ^[7]

关键词 RXFP3 RXFP4 WNN0109-C011 agonist high-throughput screening

医学主题词剂量效应关系, 药物(Dose-Response Relationship, Drug);高通量筛选分析(High-Throughput Screening Assays);人类(Humans);模型, 分子(Models, Molecular);受体, G-蛋白偶联(Receptors, G-Protein-Coupled);受体, 肽(Receptors, Peptide);小分子化合物库(Small Molecule Libraries)

DOI 10.3390/molecules26247511

PMID 34946593

发布时间 2022-02-11

基金项目

81872915 (M.-W.W.), 82073904 (M.-W.W.), 81573479 (DHY) and 81773792 (DHY)/National Natural Science Foundation of China 2018ZX09735-001 to M-WW, 2018ZX09711002-002-005 to DHY and 2018ZX09711002-002-011 to QL/National Science & Technology Major Project "Key New Drug Creation and Manufacturing Pro-gram" of China 2018YFA0507000 (M-WW)/National Key R&D Program of China NNCAS-2017-1-CC to DHY/Novo Nordisk-CAS Research Fund to RADB/Victorian Government's Operational Infrastructure Support Program

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