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首页> International journal of molecular sciences> Identification of Novel Therapeutic Targets for Polyglutamine Diseases That Target Mitochondrial Fragmentation.

Identification of Novel Therapeutic Targets for Polyglutamine Diseases That Target Mitochondrial Fragmentation.

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作者： Annika,Traa ^[1] ; Emily,Machiela ^[2] ; Paige D,Rudich ^[3] ; Sonja K,Soo ^[4] ; Megan M,Senchuk ^[1] ; Jeremy M,Van Raamsdonk ^[2]

作者单位： Department of Neurology and Neurosurgery, McGill University, Montreal, QC H3A 2B4, Canada. ^[1] Metabolic Disorders and Complications Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada. ^[2] Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada. ^[3] Laboratory of Aging and Neurodegenerative Disease, Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA. ^[4] Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC H4A 3J1, Canada. ^[5] Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. ^[6]

关键词 C. elegans DRP1 Huntington’s disease genetics mitochondria mitochondrial dynamics polyglutamine diseases

主题词动物(Animals);秀丽新小杆线虫(Caenorhabditis elegans);漂亮新小杆线虫蛋白质类(Caenorhabditis elegans Proteins);疾病模型, 动物(Disease Models, Animal);药物释放系统(Drug Delivery Systems);人类(Humans);杭廷顿病(Huntington Disease);线粒体(Mitochondria);线粒体蛋白质类(Mitochondrial Proteins);RNA干扰(RNA Interference)

DOI 10.3390/ijms222413447

PMID 34948242

发布时间 2022-01-10

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International journal of molecular sciences

International journal of molecular sciences

2021年22卷24期

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