Restoration of DNA repair mitigates genome instability and increases productivity of Chinese hamster ovary cells.

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第一作者： Philipp N,Spahn

第一单位： Department of Pediatrics, University of California, San Diego, La Jolla, California, USA.

作者： Philipp N,Spahn ^[1] ; Xiaolin,Zhang ^[2] ; Qing,Hu ^[3] ; Huiming,Lu ^[4] ; Nathaniel K,Hamaker ^[5] ; Hooman,Hefzi ^[3] ; Shangzhong,Li ^[6] ; Chih-Chung,Kuo ^[6] ; Yingxiang,Huang ^[6] ; Jamie C,Lee ^[1] ; Anthony J,Davis ^[1] ; Peter,Ly ^[6] ; Kelvin H,Lee ^[5] ; Nathan E,Lewis ^[4]

作者单位： Department of Pediatrics, University of California, San Diego, La Jolla, California, USA. ^[1] The Novo Nordisk Foundation Center for Biosustainability at the University of California, San Diego School of Medicine, San Diego, La Jolla, California, USA. ^[2] Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA. ^[3] Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ^[4] Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ^[5] Department of Bioengineering, University of California, San Diego, La Jolla, California, USA. ^[6]

关键词 CHO DNA repair cell line instability protein expression

主题词动物(Animals);CHO细胞(CHO Cells);仓鼠亚科(Cricetinae);仓鼠属(Cricetulus);DNA修复(DNA Repair);基因组不稳定性(Genomic Instability);核型分析(Karyotyping)

DOI 10.1002/bit.28016

PMID 34953085

发布时间 2023-03-02

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