Pharmacological inhibition of IRAK1 and IRAK4 prevents endothelial inflammation and atherosclerosis in ApoE<sup>-/-</sup> mice.

导出 LinkOut

翻译打印收藏纠错

作者： Xiumei,Wu ^[1] ; Mengyun,Xu ^[2] ; Zhenghong,Liu ^[2] ; Zhidan,Zhang ^[2] ; Yujie,Liu ^[2] ; Sihui,Luo ^[2] ; Xueying,Zheng ^[2] ; Peter J,Little ^[3] ; Suowen,Xu ^[4] ; Jianping,Weng ^[5]

作者单位： Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, 510000 Guangzhou, China. ^[1] Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China. ^[2] School of Pharmacy, University of Queensland, Pharmacy Australia Centre of Excellence, Woolloongabba, QLD, Australia. ^[3] Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China; Biomedical Sciences and Health Laboratory of Anhui Province, University of Science and Technology of China, Hefei 230027, China. Electronic address: sxu1984@ustc.edu.cn. ^[4] Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, 510000 Guangzhou, China; Institute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China; Biomedical Sciences and Health Laboratory of Anhui Province, University of Science and Technology of China, Hefei 230027, China. Electronic address: wengjp@ustc.edu.cn. ^[5]

关键词 Cardiovascular disease Endothelial cells IRAK1 IRAK4 Inflammation