Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP<sub>3</sub>.
第一作者:
Jennifer N,Cash
第一单位:
Department of Pharmacology, Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109-2216, USA.
作者:
关键词
DEP, dishevelled, Egl-10, and pleckstrinDH, Dbl homologyDSF, differential scanning fluorimetryDTT, dithiothreitolEDTA, ethylenediaminetetraaceticGβγ, G protein β and γ subunitsIP4P, inositol polyphosphate 4-phosphataseIns(1,3,4,5)P4, inositol-1,3,4,5-tetrakisphosphateMBP, maltose binding proteinP-RexP-Rex, phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchangerPDZ, post-synaptic density protein, Drosophila disc large tumor suppressor, and zonula occludens-1 proteinPH, pleckstrin homologyPIP3, phosphatidylinositol 3,4,5-trisphosphatePMSF, phenylmethylsulfonyl fluoridePTEN, phosphatase and tensin homologPhosphatidylinositol 3,4,5-trisphosphatePleckstrin homology domainRho guanine nucleotide exchange factorRhoGEF, Rho guanine-nucleotide exchange factor
DOI
10.1016/j.yjsbx.2018.100001
PMID
34958187
发布时间
2023-01-06
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Journal of structural biology
100001页
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