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Identification of a Thyroid Hormone Derivative as a Pleiotropic Agent for the Treatment of Alzheimer's Disease.

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第一作者： Massimiliano,Runfola

第一单位： Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.

作者： Massimiliano,Runfola ^[1] ; Michele,Perni ^[2] ; Xiaoting,Yang ^[2] ; Maria,Marchese ^[3] ; Andrea,Bacci ^[1] ; Serena,Mero ^[3] ; Filippo M,Santorelli ^[3] ; Beatrice,Polini ^[4] ; Grazia,Chiellini ^[4] ; Daniela,Giuliani ^[5] ; Antonietta,Vilella ^[5] ; Martina,Bodria ^[5] ; Eleonora,Daini ^[5] ; Eleonora,Vandini ^[5] ; Simon,Rudge ^[6] ; Sheraz,Gul ^[7] ; Michale O J,Wakelam ^[6] ; Michele,Vendruscolo ^[2] ; Simona,Rapposelli ^[8]

作者单位： Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy. ^[1] Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK. ^[2] Molecular Medicine, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Fondazione Stella Maris, Via dei Giacinti 2, 56128 Calambrone, Italy. ^[3] Department of Pathology, University of Pisa, Via Savi 10, 56126 Pisa, Italy. ^[4] Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy. ^[5] Ibabraham Research Campus, The Babraham Institute, Cambridge CB22 3AT, UK. ^[6] Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Schnackenburgallee 114, 22525 Hamburg, Germany.;Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Hamburg Site, Schnackenburgallee 114, 22525 Hamburg, Germany. ^[7] Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.;CISUP, Center for Instrument Sharing, University of Pisa, 56126 Pisa, Italy. ^[8]

关键词 5XFAD mice Alzheimer’s disease C. elegans autophagy drug discovery polypharmacology zebrafish

DOI 10.3390/ph14121330

PMID 34959730

发布时间 2023-11-08

基金项目

P40 OD010440/OD/NIH HHS/United States

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