Screening and identification of Lassa virus endonuclease-targeting inhibitors from a fragment-based drug discovery library.

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作者： Xiaohao,Lan ^[1] ; Yueli,Zhang ^[1] ; Xiaoying,Jia ^[2] ; Siqi,Dong ^[2] ; Yang,Liu ^[3] ; Mengmeng,Zhang ^[1] ; Jiao,Guo ^[2] ; Junyuan,Cao ^[2] ; Yu,Guo ^[4] ; Gengfu,Xiao ^[5] ; Wei,Wang ^[6]

作者单位： State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300450, China. ^[1] State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; University of the Chinese Academy of Sciences, Beijing, 100049, China. ^[2] State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China. ^[3] College of Pharmacy and State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin, 300450, China. ^[4] State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; University of the Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: xiaogf@wh.iov.cn. ^[5] State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; University of the Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: wangwei@wh.iov.cn. ^[6]

关键词 Benzotriazole compounds Cap-snatching Endonuclease (EN)Fragment-based drug discovery (FBDD)Lassa virus (LASV)Lymphocytic choriomeningitis virus (LCMV)Severe fever with thrombocytopenia syndrome virus (SFTSV)