首页> Cancer immunology, immunotherapy : CII> Local radiotherapy and E7 RNA-LPX vaccination show enhanced therapeutic efficacy in preclinical models of HPV16<sup>+</sup> cancer.

Local radiotherapy and E7 RNA-LPX vaccination show enhanced therapeutic efficacy in preclinical models of HPV16<sup>+</sup> cancer.

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第一作者： Nadja,Salomon

第一单位： TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstraße 12, 55131, Mainz, Germany.

作者： Nadja,Salomon ^[1] ; Abderaouf,Selmi ^[1] ; Christian,Grunwitz ^[2] ; Anthony,Kong ^[3] ; Eliana,Stanganello ^[1] ; Jennifer,Neumaier ^[1] ; Jutta,Petschenka ^[4] ; Mustafa,Diken ^[5] ; Sebastian,Kreiter ^[5] ; Özlem,Türeci ^[2] ; Ugur,Sahin ^[6] ; Fulvia,Vascotto ^[7]

作者单位： TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstraße 12, 55131, Mainz, Germany. ^[1] Biopharmaceutical New Technologies (BioNTech) SE, Mainz, Germany. ^[2] TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstraße 12, 55131, Mainz, Germany.;Comprehensive Cancer Centre, King's College London, London, UK. ^[3] TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstraße 12, 55131, Mainz, Germany.;Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany. ^[4] TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstraße 12, 55131, Mainz, Germany.;Biopharmaceutical New Technologies (BioNTech) SE, Mainz, Germany. ^[5] Biopharmaceutical New Technologies (BioNTech) SE, Mainz, Germany.;Research Center for Immunotherapy (FZI), University Medical Center at the Johannes Gutenberg University, Mainz, Germany. ^[6] TRON - Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstraße 12, 55131, Mainz, Germany. fulvia.vascotto@tron-mainz.de. ^[7]

关键词 Anti-tumoral CD8+ T cells HPV16 E6/E7 cancer Local radiotherapy RNA vaccines Tumor environment