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Genome-wide DNA methylome and transcriptome changes induced by inorganic nanoparticles in human kidney cells after chronic exposure.

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第一作者： Andrea,Soltysova

第一单位： Department of Molecular Biology, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovicova 6, 841 04, Bratislava, Slovakia.;Institute of Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, 845 05, Bratislava, Slovakia.

作者： Andrea,Soltysova ^[1] ; Patricia,Begerova ^[2] ; Kristina,Jakic ^[2] ; Katarina,Kozics ^[2] ; Monika,Sramkova ^[2] ; Eckart,Meese ^[3] ; Bozena,Smolkova ^[2] ; Alena,Gabelova ^[4]

作者单位： Department of Molecular Biology, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovicova 6, 841 04, Bratislava, Slovakia.;Institute of Clinical and Translational Research, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, 845 05, Bratislava, Slovakia. ^[1] Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, 845 05, Bratislava, Slovakia. ^[2] Institute of Human Genetics, Saarland University, Building 60, 66421, Homburg, Germany. ^[3] Cancer Research Institute, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, 845 05, Bratislava, Slovakia. alena.gabelova@savba.sk. ^[4]

关键词 Epigenetic toxicity Genome-wide methylome analysis Human renal cells Inorganic nanoparticles Whole transcriptome analysis

医学主题词人类(Humans);金(Gold);金属纳米粒子(Metal Nanoparticles);DNA甲基化(DNA Methylation);肾(Kidney)

DOI 10.1007/s10565-021-09680-3

PMID 34973136

发布时间 2023-10-06

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