Minocycline improves the functional recovery after traumatic brain injury via inhibition of aquaporin-4.

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作者： Qi,Lu ^[1] ; Jun,Xiong ^[1] ; Yuan,Yuan ^[1] ; Zhanwei,Ruan ^[2] ; Yu,Zhang ^[3] ; Bo,Chai ^[1] ; Lei,Li ^[1] ; Shufang,Cai ^[1] ; Jian,Xiao ^[4] ; Yanqing,Wu ^[1] ; Peng,Huang ^[4] ; Hongyu,Zhang ^[5]

作者单位： School of Pharmaceutical Sciences, Wenzhou Wound Repair and Regeneration Key Laboratory, Cixi Biomedical Research Institute, Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China. ^[1] Department of pharmacy, Hangzhou Red Cross Hospital, Zhejiang Province Hospital of Integrated Traditional Chinese and Western Medicine, 310003, Hangzhou, Zhejiang, China. ^[2] Department of Emergency, Ruian People's Hospital, The Third Affiliated Hospital of Wenzhou Medical University, 325000, Wenzhou, Zhejiang, China. ^[3] The Institute of Life Sciences, Engineering Laboratory of Zhejiang Province for Pharmaceutical Development of Growth Factors, Biomedical Collaborative Innovation Center of Wenzhou, Wenzhou University, 325035, Wenzhou, Zhejiang, China. ^[4] Department of Pharmacy, Ruian People's Hospital, The Third Affiliated Hospital of Wenzhou Medical University, 325200, Wenzhou, Zhejiang, China. ^[5] Department of Pharmacy, Zhuji People's Hospital, The Affiliated Hospital of Wenzhou Medical University, 311899, Shaoxing, Zhejiang, China. ^[6]

关键词 Astrocytes Blood-brain barrier (BBB)Minocycline, Aquaporin-4 (AQP4)Traumatic brain injury (TBI)