Tumor-Acidity and Bioorthogonal Chemistry-Mediated On-Site Size Transformation Clustered Nanosystem to Overcome Hypoxic Resistance and Enhance Chemoimmunotherapy.

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作者： Kewei,Wang ^[1] ; Maolin,Jiang ^[2] ; Jielian,Zhou ^[1] ; Ye,Liu ^[2] ; Qingyu,Zong ^[1] ; Youyong,Yuan ^[3]

作者单位： School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou 511442, P. R. China. ^[1] National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, P. R. China. ^[2] Guangdong Provincial Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou 510006, P. R. China. ^[3] Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, P. R. China. ^[4]

关键词 bioorthogonal chemistry chemoresistance hypoxia immunogenic cell death nitric oxide on-site size transformation

主题词人类(Humans);多柔比星(Doxorubicin);肿瘤(Neoplasms);纳米粒子(Nanoparticles);免疫疗法(Immunotherapy);肿瘤微环境(Tumor Microenvironment);细胞系, 肿瘤(Cell Line, Tumor)

DOI 10.1021/acsnano.1c08232

PMID 34978422

发布时间 2022-11-16

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准确一般字义偏差语意偏离译文作用小提交