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Engineered High-Affinity ACE2 Peptide Mitigates ARDS and Death Induced by Multiple SARS-CoV-2 Variants.

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第一作者： Lianghui,Zhang

第一单位： Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL 60612, USA.

作者： Lianghui,Zhang ^[1] ; Soumajit,Dutta ^[2] ; Shiqin,Xiong ^[1] ; Matthew,Chan ^[2] ; Kui K,Chan ^[3] ; Timothy M,Fan ^[4] ; Keith L,Bailey ^[4] ; Matthew,Lindeblad ^[5] ; Laura M,Cooper ^[6] ; Lijun,Rong ^[6] ; Anthony F,Gugliuzza ^[1] ; Diwakar,Shukla ^[2] ; Erik,Procko ^[7] ; Jalees,Rehman ^[8] ; Asrar B,Malik ^[1]

作者单位： Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL 60612, USA. ^[1] Department of Chemical and Biomolecular Engineering, University of Illinois, Urbana, IL 61801, USA. ^[2] Cyrus Biotechnology, Inc., Seattle, WA 98101, USA. ^[3] Department of Veterinary Clinical Medicine, University of Illinois College of Veterinary Medicine, Urbana, IL 61802, USA. ^[4] Toxicology Research Laboratory, Department of Pharmacology and Regenerative Medicine, The University of Illinois College of Medicine, Chicago, IL 60612, USA. ^[5] Department of Microbiology and Immunology, The University of Illinois College of Medicine, Chicago, IL 60612, USA. ^[6] Department of Biochemistry, University of Illinois, Urbana, IL 61801, USA. ^[7] Department of Pharmacology and Regenerative Medicine and the Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL 60612, USA.;Division of Cardiology, Department of Medicine, The University of Illinois College of Medicine, Chicago, IL 60612, USA. ^[8]

DOI 10.1101/2021.12.21.473668

PMID 34981059

发布时间 2024-08-20

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Engineered High-Affinity ACE2 Peptide Mitigates ARDS and Death Induced by Multiple SARS-CoV-2 Variants.

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Engineered High-Affinity ACE2 Peptide Mitigates ARDS and Death Induced by Multiple SARS-CoV-2 Variants.

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