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首页> BMC pharmacology & toxicology> Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro.

Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro.

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作者： Julius T,Dongdem ^[1] ; Gideon K,Helegbe ^[2] ; Kwame,Opare-Asamoah ^[3] ; Cletus A,Wezena ^[4] ; Augustine,Ocloo ^[5]

作者单位： Department of Biochemistry and Molecular Medicine, School of Medicine, University for Development Studies, Tamale-Campus, Tamale, Ghana. julius.dongdem@uds.edu.gh. ^[1] School of Life Sciences, University of Nottingham Medical School, NG7 2UH, Nottinghamshire, UK. julius.dongdem@uds.edu.gh. ^[2] Department of Biochemistry and Molecular Medicine, School of Medicine, University for Development Studies, Tamale-Campus, Tamale, Ghana. ^[3] Department of Physiology and Biophysics, School of Medicine, University for Development Studies, Tamale-Campus, Tamale, Ghana. ^[4] Department of Microbiology, Faculty of Bioscience, University for Development Studies, Nyankpala Campus, Tamale, Ghana. ^[5] Department of Biochemistry, Cell and Molecular Biology University of Ghana, Legon, Accra, Ghana. ^[6]

关键词 Affinity Arachidonamide FAAH-1 Hydrolysis Inhibition Mode NSAIDs Oleamide Stearoylamide

主题词酰胺基水解酶类(Amidohydrolases);动物(Animals);消炎药, 非甾类(Anti-Inflammatory Agents, Non-Steroidal);花生四烯酸类(Arachidonic Acids);酶抑制剂(Enzyme Inhibitors);脂肪酸类(Fatty Acids);人类(Humans);多不饱和脂肪酸酰胺类(Polyunsaturated Alkamides);大鼠(Rats)

DOI 10.1186/s40360-021-00539-1

PMID 34983657

发布时间 2022-03-16

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BMC pharmacology & toxicology

BMC pharmacology & toxicology

2022年23卷1期

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