HLF regulates ferroptosis, development and chemoresistance of triple-negative breast cancer by activating tumor cell-macrophage crosstalk.

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作者： Hengyu,Li ^[1] ; Pinghua,Yang ^[2] ; JingHan,Wang ^[2] ; Jin,Zhang ^[3] ; Qianyun,Ma ^[2] ; Yingjie,Jiang ^[4] ; Yani,Wu ^[5] ; Tao,Han ^[6] ; Daimin,Xiang ^[7]

作者单位： Department of Breast and Thyroid Surgery, Changhai Hospital, Naval Military Medical University, 230 Changhai Road, Shanghai, 200433, China. lhy@smmu.edu.cn. ^[1] Department of Hepatic Surgery, Third Affiliated Hospital of Naval Military Medical University, Shanghai, 200438, China. ^[2] Department of Hepatobiliary Surgery, East Hospital, School of Medicine, Tongji University, Shanghai, 200120, China. ^[3] Department of Urology Surgery, Changhai Hospital, Naval Military Medical University, Shanghai, 200433, China. ^[4] Department of Pathology, Changhai Hospital, Naval Military Medical University, Shanghai, 200433, China. ^[5] Department of Breast and Thyroid Surgery, Changhai Hospital, Naval Military Medical University, 230 Changhai Road, Shanghai, 200433, China. ^[6] Department of Oncology, The First Affiliated Hospital of China Medical University, 155 Nanjing North Street, Shenyang, 110001, China. than1984@sina.com. ^[7] State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, No. 25, Lane 2200, Xietu Road, Shanghai, 200127, China. xdm20079@126.com. ^[8]

关键词 Ferroptosis GGT1 TGF-β1/SMAD3/HLF/IL-6/JAK2/STAT3 pathway Triple-negative breast cancer Tumor-associated macrophages

主题词抗肿瘤药(Antineoplastic Agents);碱性亮氨酸拉链转录因子类(Basic-Leucine Zipper Transcription Factors);抗药性, 肿瘤(Drug Resistance, Neoplasm);女(雌)性(Female);人类(Humans);肿瘤微环境(Tumor Microenvironment)

DOI 10.1186/s13045-021-01223-x

PMID 34991659

发布时间 2022-02-15

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