Clinicopathologic and molecular features of denosumab-treated giant cell tumour of bone (GCTB): Analysis of 21 cases.

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作者： Li,Yang ^[1] ; Hongjuan,Zhang ^[1] ; Xiaohui,Zhang ^[2] ; Yongqiang,Tang ^[3] ; Zhigang,Wu ^[4] ; Yingmei,Wang ^[1] ; Hai,Huang ^[4] ; Xin,Fu ^[1] ; Jiayan,Liu ^[1] ; Pancras C W,Hogendoorn ^[5] ; Hong,Cheng ^[6]

作者单位： State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi'an, Shaanxi province, China. ^[1] Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. ^[2] Department of Radiology, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi province, China. ^[3] Department of Orthopaedics, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi province, China. ^[4] Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: p.c.w.hogendoorn@lumc.nl. ^[5] State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, the Fourth Military Medical University, Xi'an, Shaanxi province, China. Electronic address: chenghongfmmu85@yahoo.com. ^[6]

关键词 Bone neoplasm Denosumab Giant cell tumour of bone H3.3 G34W H3F3A Histological features Histone mutation Immunohistochemistry