Discovery of highly potent SARS-CoV-2 M<sup>pro</sup> inhibitors based on benzoisothiazolone scaffold.

导出 OA

翻译打印收藏纠错

第一作者： Weixiong,Chen

第一单位： School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

作者： Weixiong,Chen ^[1] ; Bo,Feng ^[2] ; Sheng,Han ^[3] ; Peipei,Wang ^[3] ; Wuhong,Chen ^[3] ; Yi,Zang ^[4] ; Jia,Li ^[5] ; Youhong,Hu ^[6]

作者单位： School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ^[1] School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, No.103 Wenhua Road, Shenyang 110016, China. ^[2] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ^[3] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China. Electronic address: yzang@simm.ac.cn. ^[4] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, No.103 Wenhua Road, Shenyang 110016, China; Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei Jimo, Qingdao 266237, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China. Electronic address: jli@simm.ac.cn. ^[5] School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China. Electronic address: yhhu@simm.ac.cn. ^[6]

关键词 Benzoisothiazolone COVID-19 Main protease inhibitors SARS-CoV-2

主题词抗病毒药(Antiviral Agents);药物发现(Drug Discovery);人类(Humans);微生物敏感性试验(Microbial Sensitivity Tests);分子结构(Molecular Structure);蛋白酶抑制药(Protease Inhibitors);噻唑类(Thiazoles)

DOI 10.1016/j.bmcl.2022.128526

PMID 34998903

发布时间 2022-12-21

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交