Inhibition of histone demethylase KDM4 by ML324 induces apoptosis through the unfolded protein response and Bim upregulation in hepatocellular carcinoma cells.

导出 LinkOut

翻译打印收藏纠错

作者： So Young,Kim ^[1] ; Supyong,Hwang ^[2] ; Bo Ra,Lee ^[2] ; Jung A,Hong ^[2] ; Young Hoon,Sung ^[3] ; Inki,Kim ^[4]

作者单位： Biomedical Research Center, ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, 05505, Republic of Korea. Electronic address: visionbook@amc.seoul.kr. ^[1] Convergence Medicine Research Center (CREDIT), ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, 05505, Republic of Korea. ^[2] Biomedical Research Center, ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, 05505, Republic of Korea; Convergence Medicine Research Center (CREDIT), ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, 05505, Republic of Korea; Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea. ^[3] Biomedical Research Center, ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, 05505, Republic of Korea; Convergence Medicine Research Center (CREDIT), ASAN Institute for Life Sciences, ASAN Medical Center, Seoul, 05505, Republic of Korea; Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, 05505, Republic of Korea. Electronic address: ik.kim@amc.seoul.kr. ^[4]

关键词 Bim Death receptor 5 Hepatocellular carcinoma Lysine demethylase 4 ML324 Unfolded protein response